Enhancing CD8+ T Cell Immunity Using Microbiota-Derived Short Chain Fatty Acids

Microbiota-derived butyrate promotes a FOXO1-induced stemness program and preserves CD8 T cell immunity against melanoma

A Bachem, M Clarke, G Kong, I Tarasova, L Dryburgh, L Kosack, AR Lee, LD Newland, T Wagner, E Bawden, KM Yap, MD Wilson, S Engel, KR Wilson, BE Russ, K Tandon, PKH Lau, G McArthur, VR Marcelino, PA Beavis

2025-11-11

A range of microbiota species correlate with improved cancer outcomes in patients and confer protection in pre-clinical mouse mode..